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146 Although lack of exhaustive research on mechanism, fat accumulation in the pancreas is associated with cell lipotoxicity, which may be enhanced from local paracrine pathways

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In some cases, there is also an increased risk of cancer, especially with metals like arsenic, which are known carcinogens

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Estrogenic activity of standardized extract of Angelica sinensis

141 Inactivation of p53 Mechanisms of mutation and aggregation TP53 somatic mutations Among somatically mutated genes, TP53 mutations are the most common