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Metabolomic analysis We used Biocrates AbsoluteIDQ p180 kit to analyze cardiac metabolites from female mice [Young ( n = 7), Old Con ( n = 8), and Old mAb ( n = 7)] with UPLC-MS/MS Xevo TQ, Waters, Pittsburgh, PA, USA) in the Einstein Stable Isotope and Metabolomics Core, according to the manufacturers instructions (BIOCRATES Life Sciences AG, Innsbruck, Austria)

63 , this study demonstrates the role of the FANCMBTR complex in alleviating replication stress at ALT-positive telomeres and provides the first evidence for the FANCMBTR interaction as a novel drug target

Injections are typically self-administered once weekly

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