Some had too little or none of the active ingredient
Appetite effects: Act on brain regions controlling hunger and fullness Reduce appetite between meals Enhance feelings of satisfaction after eating Decrease food preoccupation and cravings Gastric effects: Slow stomach emptying Prolong feelings of fullness Reduce the volume of food needed to feel satisfied Metabolic effects: Improve insulin secretion (glucose-dependent) Reduce glucagon release Improve insulin sensitivity Both Saxenda and Ozempic work through these mechanisms
This approach has emerged largely through social media, with individuals attempting to minimise side effects whilst seeking some therapeutic benefit
Nature Medicine, 28(11), 22222233
Patients should reach out if they experience persistent nausea, vomiting, or diarrhea that prevents adequate nutrition or hydration (which may lead to dehydration and kidney problems)
Common Side Effects Nausea Vomiting Diarrhea Constipation Decreased appetite Stomach discomfort or bloating Injection site reactions such as redness or mild swelling Less Common Side Effects Fatigue during the first few weeks Heartburn or acid reflux Headache Dizziness If side effects feel unmanageable at the Retatrutide starting dose, speak with your doctor before making any changes
