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This latest treatment offers minimally invasive surgery for a disease with devastating outcomes

Cellular iron metabolism

Combination regimens (e.g., methotrexate + leflunomide) enhance efficacy but increase toxicity, with 15 - 20% of patients experiencing severe adverse events (6)

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The honest summary is therefore: mechanistically rich, preclinically supported (but not uniformly) for tissue repair in animals, and clinically unproven in humans