223,224 GLP-1 also inhibits glucagon release from -cells, which is beneficial for reducing blood glucose levels since glucagon promotes hepatic gluconeogenesis
The hTYR pocket is more acidic, whereas the mTYR pocket is more hydrophobic, indicating some differences between the two enzymes
[1] [6] Common dosing protocols in clinical studies have ranged from 600 mg to 1,400 mg per session, administered two to three times per week, though higher or lower doses may be used depending on individual needs
Sharma S, Le Guillou D, Chen JY
doi: 10.1016/j.celrep.2021.109839
This effect is believed to come from B12s support of neurotransmitters such as serotonin and dopamine, which influence cognitive function and emotional balance