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In some embodiments, the mucoadhesive agent is an alkyl-glycoside wherein the alkyl glycoside is maltose, sucrose, glucose, or a combination thereof linked by a glycosidic linkage to an alkyl chain of 9-16 carbon atoms (e.g., nonyl-, decyl-, dodecyl- and tetradecyl sucroside

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Primarily through amyloid-preventing substitutions at residues 20-29, addition of the C18 fatty diacid lipid group, and optimization of the linker