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These three peroxidases also contribute to the fluoroquinolone persistence mechanism, which is closely associated with the oxidative stress response in S

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Individual vulnerability varies significantly based on nutritional status, liver function, age, and genetic polymorphisms in detoxification enzymes

GTP-bound RhoA activates ROK, which phosphorylates and thereby inhibits MLCP, enhancing MLC phosphorylation mediated by myosin light chain kinase (MLCK), and ultimately promoting smooth muscle contraction (Kimura et al., 1996)