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The review revisited SUSTAIN-6, where semaglutide-treated patients showed a hazard ratio of 1.76 for retinopathy complications compared with placebo. The discussion has since shifted toward whether rapid metabolic changerather than direct retinal toxicitymay explain the signal

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Notably, the treatment demonstrated antiallodynic effects, meaning that it alleviated pain caused by stimuli that wouldnt normally induce pain in a non-inflamed subject