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Excessive Caffeine Moderate coffee intake is generally fine, but overconsumption of caffeine raises cortisol levels and contributes to oxidative stress

Methods Search strategy and selection criteria The systematic review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD420251088025

Biomed Pharmacother = Biomed Pharmacother (2020) 130:110523

This temporal difference means the two agents may complement each other if patient monitoring is rigorous and dosing is conservative