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In the UK, adults aged 15 and over require 1.5 micrograms (mcg) per day, according to the Department of Health's Reference Nutrient Intake

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Recurrent episodes in a separate pre-clinical OM model also demonstrated continuous microevolution of a haemoglobin-binding gene that resulted in a highly invasive NTHi phenotype that persisted for at least one month following clinical resolution of the infection (Harrison et al., 2020)