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The GSTF8 gene was also induced by H 2 O 2 through the activation of MPK3/MPK6 kinases (Kovtun et al., 2000) the promoter of which contains an as-1 motif, which is implicated in response to oxidative stress (Garretn et al., 2002)

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The molecular mechanisms and signaling pathways by which GLP-1 improves sarcopenia.GLP-1 binds to GLP-1RA and exerts physiological effects through the PI3K/Akt and cAMP/PKA signaling pathways.GLP-1 mainly promotes muscle protein synthesis through the PI3K/Akt/mTORC1 pathway.The catabolism of muscle is mediated by specific transcription factors, such as FOXO proteins and NF-KB, and the activation of these transcription factors is triggered by extracellular stimuli or JAK-STAT signaling.GLP-1 can also improve mitochondrial function, reduce oxidative stress, and promote autophagy