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Description

Lysinuric protein intolerance: reviewing concepts on a multisystem disease

Updated for 2026

MET = Metformin

Data show that up to two-thirds of patients with HFpEF have CAD or coronary microvascular dysfunction including ischaemia, which leads to disruption of LV diastolic and systolic function, development of fibrosis, increased myocardial stiffness and cardiac remodelling