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Verdict at a Glance CagriSema and retatrutide represent two fundamentally different approaches to next-generation obesity treatment

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Arms and Thighs Rapid weight loss can also leave loose or crepey skin along the upper arms and thighs, especially in patients who have lost a substantial amount of weight

Common signs of B12 deficiency include persistent fatigue and weakness, related to anemia caused by impaired red blood cell production

This multi-receptor mechanism distinguishes it from earlier agents such as semaglutide and tirzepatide

Additionally, Arg at the 34th position is replaced with Lys to accommodate site-specific acylation