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53 Following activation, the former competitively inhibits molecules that stimulate drug resistance, while the nitrogen-mustard segment induces apoptotic activity by influencing the activities of MAPK, p38 kinase, JNK, MKK4, and caspase 3

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In another randomized clinical trial, CB-839 did not enhance the therapeutic efficacy of cabozantinib in metastatic RCC (Tannir et al., 2021)

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10.1074/jbc.R700026200