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In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimers disease model

Acute signaling responses occur within hours to days, protein synthesis changes manifest over days to weeks, and structural adaptations like muscle hypertrophy need weeks to months

11 53BP1 and 53BP2 were first identified to bind to p53 and interact with the p53-DBD via the L2 and L3 loops

Another study of the same group, Reger et al

Under oxidative stress, accumulation of ROS can activate pathways such as the JNK and the p53, further inducing autophagy, which helps clear damaged organelles, reduces oxidative damage, and protects cell survival [256]

Wrinkle reduction: Particularly around the eyes and forehead