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A subtype of adenosine receptors, the A2A receptor, has been identified as the target gene of HIF-1 in alveolar epithelium contributes to lung protection during ALI [69]

The exact mechanism whereby inflammation might act in tumour development and progression remains to be elucidated, but is likely to be complex

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doi: 10.1016/j.cell.2008.07.021, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 92

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134 The NLRP3 is also upregulated resulting from activated NF-B, and activates caspase 1 which induces cell pyroptosis, a type of programmed cell death characterized by the formation of pores in the plasma membrane, leading to the release of proinflammatory cytokines and subsequent cell lysis 38,135 (Fig