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Microbiological Reviews, 59 , 143169

B12 is essential for the methylation reactions required to produce the lipids and proteins that constitute myelin

NRF2 gene are clustered within the DLG (43%) and ETGE (57%) motifs ( Figure 6B ), which are critical sites for the binding of Nrf2 to the Keap1 DC domain

B-12 deficiency has also been linked to migraine headaches and menstrual irregularities. Recent research has shown that higher levels of Vitamin B-12 protect against brain changes that happen with aging.People with higher B-12 levels, even those without actual deficiency showed less age-related decline like dementia and Alzheimers disease

Maurice and Manousou, 2018)

References 1.Bus JS, Gibson JE