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(2017) 26:34352.e2

Watch for clinical signs of copper excess: new or worsening jaundice, Kayser-Fleischer ring formation on slit-lamp exam (rare but pathognomonic), unexplained hemolytic anemia, or rising transaminases without alternative explanation [2]

Subjects had their main meals at the transition time zones of the day, including pre-dawn breakfast (at the first transition time of the day) and dinner at sunset (at the second transition time of the day) and were allowed to eat (e.g., snacks) or drink if they needed between sunset and dawn in addition to the pre-dawn breakfast and dinner at sunset

Circulation 148 , 20382057 (2023)

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