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lean-adjacent n=1 case lost about a third of weight as muscle on 2.5 mg, recovered with resistance work and protein: Almandoz Obes Pillars 2026

In this context, recognition of SAGE-DM may have practical implications by encouraging clinicians to consider alternative therapeutic priorities, including preservation of muscle mass, avoidance of overtreatment, correction of hormonal and nutritional imbalances, and individualized metabolic targets

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