GLP-1RAs should be discontinued immediately if pancreatitis is suspected and are generally avoided in patients with a prior history of pancreatitis
The mechanism of action includes stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release , slowing gastric emptying , and acting centrally on the hypothalamus and brainstem to increase satiety and reduce appetite
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Patients were grouped based on whether they regained weight, maintained their weight loss, or experienced further weight reduction
Wegovy contains semaglutide, which belongs to a class of drugs called GLP-1 receptor agonists
It encodes a preproglucagon of 180 aa residues that contains glucagon, GLP-1, and GLP-2