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Similarly the weight loss seen with Exenatide and some other early GLP-1 drugs was thought too limited to win approval for the treatment of obesity (Gilbert, Rosenthal, March 2024)

In a similar patient population of adults with obesity who did not have diabetes, no severe or blood glucose-confirmed symptomatic hypoglycemic events were reported with semaglutide 1.0 mg [26]

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GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle

Heres a rapid-fire list of typical solutions and then well go into specifics of each