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And while addressing severe addiction is a real and non-trivial pursuit, the already present ease of accessibility (even to children as young as 12) makes this a much broader societal experiment in appetite and impulse regulation

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However, oral administration is gaining traction, led by Rybelsus, the first oral GLP-1 approved by the FDA

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In addition to CPT2, humans express three additional carnitine acyltransferases: carnitine palmitoyltransferase 1 (CPT1 or CPT-I), carnitine O -acetyltransferase (CRAT), and carnitine octanoyltransferase (CROT)

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[1] This is not a formal contraindication, but rather a precautionary recommendation based on limited safety data in this population

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McConnachie L.A., Mohar I., Hudson F.N., Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice (.) // Toxicol Sci

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