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A typical phase 3 RCT may require a number of participant visits to a clinic, possibly adding to drop-out rates and recruitment difficulties, compounded by the long-term nature of a cancer prevention trial

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This response enhances tumor penetration and reduces systemic toxicity, making them promising tools for targeted cancer therapy (Kenchegowda et al., 2021

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However, retatrutide is still in Phase 3 trials and not yet FDA-approved, so direct real-world comparisons are not yet possible