The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Tirzepatide was compared to once-weekly oral semaglutide in the SURPASS-2 study, an open-label, phase 3 clinical trial with a 40-week follow-up that enrolled T2DM patients with a BMI of 25 kg/m 2 and an HbA1c of 710.5% despite taking at least a 1500 mg dose of metformin
Why did DPP-4 inhibitors not exert favorable renal effects when administered over these relatively short periods of time
However, they point out that their study design reduces many of the biases common to other observational studies, and results were consistent after additional analyses, providing greater confidence in their conclusions
Since the group custom survey was proprietary, we are limited in how much of it we can share, but we wanted to flag a handful of charts from the 140+ pages of insights to socialize what we have with the investment community at large
U.et al (2021)
