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Even if this diet regiment is too arduous for many or for the elderly in particular our results suggest that potential CR mimetic agents should aim to mimic the results of daily fasting, and not simply energy restriction, to fully capture the benefits of CR for AD

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Conversely, in the early luteal phase, histone acetylation at these same loci promotes transcription under the influence of LH and the cAMP/PKA signaling pathway (41)