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1 Introduction Tumor-associated macrophages (TAMs), a dominant immune cell population in the tumor microenvironment (TME), significantly influence cancer progression ( Ferroptosis represents a metabolically driven form of regulated cell death that is fundamentally distinct from apoptosis, necroptosis, and pyroptosis ( Figure 1

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Below is an overview of the principal research areas documented in preclinical studies

[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Cahalan SM, Lukacs V, Ranade SS, Chien S, Bandell M, Patapoutian A

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