Current studies have demonstrated that butyrate upregulates acetylation levels through selective inhibition of HDAC1, 2, 3, 4, and 8 [27,28,29,30,31,32,33,34,35,36,37,38,39] (Table 1)
This varies depending on the compound, the delivery method, and whats driving your symptoms
Everything in Protocol 1, plus: Protein: Minimum 90-100 grams daily total (critical, non-negotiable) Biotin: 2,500-5,000 mcg daily Iron: 18 mg daily for women (only if indicated by bloodwork for men) Zinc: 15-30 mg daily Omega-3: 1-2 grams daily Expected benefits: Reduced hair shedding, maintained hair density, faster regrowth if shedding has already begun
Medical weight loss, including GLP-1 medications, can be an effective entry point
Compounds having logP oct 2.0 have optimal brain penetration
other studies have found no significant difference