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it therefore enrolled fewer patients and was shorter in duration than would be required to show safety in a post-approval setting, and was not powered to show superiority [79, 95]

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Van Opdenbosch N, Lamkanfi M

Our results suggest that upon infection with the malaria parasite, the host RBC compartment turns mildly oxidizing and there is accumulation of GSSG and efflux of both GSH and GSSG into the medium