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Furthermore, the liraglutide treatment led to a significantly higher serum level of secreted FNDC5 derivative than the control as quantitated by the irisin ELISA assay (Figure 2H and Supplementary Figure S4), aligning well with the 50% increase of serum irisin in patients with T2D after the treatment of GLP-1RA exenatide for 12 weeks ( n = 6) that were fed with high fat diet (HFD) for 10 weeks

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Greenberger JS, Smith T, Schlesselman JJ, Epperly M