Key Findings: Most common: Nausea (43%), diarrhea (33%), vomiting (21%) Unique to retatrutide: Dysesthesia (20.9% @ 12mg in TRIUMPH-4, 8.8% @ 9mg) Discontinuation rate: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 (general obesity population) compared to semaglutide 6.9%, tirzepatide 6.2% Good news: Most side effects peak during dose escalation and improve significantly after week 16 Management: Slow titration, dietary modifications, and proper timing dramatically reduce severity Understanding the Three Categories of Side Effects 1
The blood work they do as part of the process showed me that they genuinely care about identifying any personal health risks before they become a problem
Its important to follow your healthcare providers guidance on the timing of your doses, as the specific day can be flexible, and the medication can be taken with or without food
Bruising Small bruises at injection sites are common and almost always harmless
Diabetes care 34 , 20412047, doi:10.2337/dc11-0291 (2011)
Kidney Int 102 , 248260 (2022) R
