Glycemic context: Participants were non-diabetic at baseline
Conclusion The use of GLP-1 receptor agonists as adjunct therapy in type 1 diabetes represents an evolving area in diabetes care
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The beneficial effect of tirzepatide on hsCRP, a biomarker of systemic inflammation, YKL-40, a proinflammatory cytokine, and ICAM-1, a biomarker of endothelial dysfunction, was already detectable at 4 weeks, consistent with the salutary effects of GIP and GLP-1 on inflammation and atherosclerosis in experimental models [84,85,86]
But it took months for insurance coverage to expand, and supply shortages persisted into 2024
