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had current treatment with or history of (within 3 months before visit 2) treatment with medications that may cause substantial weight gain, including but not limited to: tricyclic antidepressants, atypical antipsychotics and mood stabilizers Examples: imipramine amitriptyline mirtazapine paroxetine phenelzine chlorpromazine thioridazine clozapine olanzapine valproic acid (and its derivatives) or lithium Note: selective serotonin reuptake inhibitors other than paroxetine were permitted

The regulatory effect of NRF2 on those genes was well documented through antioxidative response element binding in the promoter or enhancers of target genes

2022 Dec;186:106550

The FDA has approved these medications for chronic weight management in adults with obesity (body mass index 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity such as hypertension, type 2 diabetes, or dyslipidemia

Heavy NNMT activity drains the methyl group supply, affecting all those downstream methylation reactions

Thats why semaglutide during menopause can help