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Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans

Comparing Semaglutide Dose Efficacy and Real-World Outcomes Pivotal trials showed that participants on 2.4 mg weekly semaglutide achieved an average weight loss of 17.4% of baseline body weight over 68 weeks, compared to 3.3% placebo

But it does mean endurance athletes should pay attention, particularly if competing under anti-doping regulations

and obesity and diabetes in the rest of the world

Monitoring makes sense for people with pre-existing thyroid conditions, but otherwise is optional

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