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It has been demonstrated that in some cases of oral mucosal melanoma, there is loss of the integrity of the melanosomal membrane with leakage into the cytoplasm and nucleoplasm of the melanocytes, of toxic melanin particles, intermediates of melanogenesis and reactive oxygen species, with consequent DNA damage and increase in the risk of genetic mutations [59]
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Sixty-four naive zebrafish were acquired from a local retailer and equally divided into four experimental groups, each comprising 16 fish with an equal male to female ratio