A diagnosis of GSSD was finally made based on intractable metabolic acidosis, jaundice, hemolytic anemia, hyperbilirubinemia, massive 5-oxoprolinuria, and the presence of compound heterozygous variants in GSS
Importantly, the 7-AHC group retained the traditional advantages of a self-eliminating leaving group
Brand manufacturers have been increasingly aggressive in challenging skinny-label generics with induced infringement claims arguing that even if the generics label does not include the patented indication, the generic manufacturer knows that physicians will prescribe it for that use
This is thought to happen from in 5-35% of patients
so many perks
Real options valuation (ROV) captures the optionality inherent in pharmaceutical IP: the option to reformulate, the option to file for a new indication, the option to license rather than commercialize