7af, ir (n = 3 for each genotype, male mice)
B12 & Methylation: Added methylcobalamin (B12) and folinic acid to support methylation and neurotransmitter balance
Cells were exposed to concentrations of LCS3 ranging from 5nM to 10M for 96 hours, and cell viability was determined using alamarBlue
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Angelman syndrome (AS) , characterized by microcephaly, seizures, motor dysfunction, and mental retardation, is a result of maternal chromosome deletions in the region 15q11-q13 associated with ubiquitin-protein ligase E3A (UBE3A) critical region [379] Angelman syndrome (AS) UBE3A encodes E6-associated protein (E6-AP), which acts as a cellular ubiquitin ligase and establishes a covalent linkage between a 76-amino acid ubiquitin molecule and its target protein to form a polyubiquitylated substrate [379]
Gonzlez-Ramos R, Van Langendonckt A, Defrre S, Lousse JC, Colette S, Devoto L, et al