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This four-amino acid sequence (Ala-Glu-Asp-Gly) was first developed by Russian scientist Professor Vladimir Khavinson in the 1980s

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Moreover, oxidative stress-induced disruptions in secretory organelles may alter the secretome of chondrocytes, impacting extracellular signaling and contributing to pathological tissue remodeling

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doi: 10.3389/fendo.2020.608428