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As body weight decreases, the body's total energy expenditure naturally declines because there is less mass to maintain

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Monteiro CA, Levy RB, Claro RM, de Castro IR, Cannon G (2011) Increasing consumption of ultra-processed foods and likely impact on human health: evidence from Brazil

Yes, severe or prolonged calorie deficits can reduce libido by disrupting sex hormone production, particularly testosterone and oestrogen

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Consistent with the marked benefits on steatosis and lobular inflammation scores, semaglutide and lanifibranor significantly reduced %-area and total levels of lipids and galectin-3 (Figs