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Side effect intensity may bump up briefly with each dose increase and then settle

The FDA boxed warning exists because, during laboratory trials, high doses of semaglutide caused a rare type of thyroid tumour (medullary thyroid carcinoma) in rats and mice

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Common side effects include nausea, vomiting, diarrhea, constipation, headache, dizziness, and injection site reactions

In biological systems, hydroxyl radicals can be formed by homolytic cleavage of water using high-energy irradiation or more probably, by redox metal-catalyzed decomposition of hydrogen peroxide (reaction 7, Fenton reaction)