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2What about NRF-2 and non-alcoholic fatty liver disease?2.1Cytosolic mechanism of NRF-2 Nuclear factor (erythroid-derived 2)-like 2 plays a transcendental role in the antioxidant and anti-inflammatory mechanism, it activates the elements of the antioxidant response (ARE) [9], all this related to Kelch-like ECH-associated protein nuclear factor (erythroid-derived 2)-like 2 (KEAP1-NRF2) [7,16]