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Oral semaglutide and injectable retatrutide are very different pharmacokinetic profiles

Naturally, I did what I always try to do: I went digging for the data

Evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimers disease

Mounjaro 15 mg gave an average weight loss of 22.5% in SURMOUNT-1, and Wegovy 7.2 mg gave 20.7% in STEP UP, a difference of around 1 to 2 percentage points