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Its mechanism of action has not been fully clarified, especially the metabolic pathways and targets in humans remain unclear

It indicates the body is having difficulty clearing iron

The Natural History of MTC in MEN2A The earliest histologic abnormality in the thyroid glands removed from children and young adults with MEN2A is single or multicentric C cell hyperplasia (Fig

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BH4 is an essential cofactor for producing aromatic amino acids, neurotransmitters, and nitric oxide in the presence of iron at the enzyme-catalyzed site

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