Current evidence suggests that obesity is a chronic condition and that ongoing treatment is often necessary to maintain the benefits achieved with GLP-1 therapy
The FDA has warned that food-grade ingredients arent suitable for compounding sterile drugs without appropriate processing because of a high risk of contamination from bacteria
Glucotoxicity results in apoptosis in H9c2 cells via alteration in redox homeostasis linked mitochondrial dynamics and polyol pathway and possible reversal with cinnamic acid
Kim J, Okamoto H, Huang Z et al (2017) Amino acid transporter Slc38a5 controls glucagon receptor inhibition-induced pancreatic alpha cell hyperplasia in mice
Adipokines imbalance (i.e., adiponectin/leptin ratio) and pro-inflammatory environment directly alter platelet function as well
It may also be suitable for those with a BMI of 27 or higher if they have weight-related conditions such as type 2 diabetes, hypertension, or high cholesterol