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A review of 38 RCTs comprising 7,551 patients on ICI therapy evaluated the incidence of endocrine irAEs and found a higher incidence of hypo and hyperthyroidism, especially in patients receiving combined ICI therapy (OR: 3.81

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however, some cells showed signs of degradation (Figure 8F)

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doi: 10.1590/abd1806-4841.20186493

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