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Opioid withdrawal in clinical practice According to the DSM-5 and as defined in the previous section, withdrawal from a substance is defined as the substance-specific problematic behavioral change, with physiologic and cognitive components, that is due to the cessation of, or reduction in, heavy and prolonged substance use and in the International Classification of Diseases, 10th edition, as a group of symptoms of variable clustering and severity occurring on absolute or relative withdrawal of a psycho-active substance after persistent use of that substance (49)

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