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Partial enteral nutrition (PEN) has been demonstrated to modulate the composition of the gut microbiota, particularly by promoting the proliferation of short-chain fatty acid (SCFA)-producing bacteria and enhancing mucosal barrier function 208

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For example, metformin-treated T2DM patients with elevated levels of Bacteroides fragilis in the gastrointestinal tract, whose metabolite glycoursodeoxycholic acid (GUDCA) is involved in inhibiting FXR signaling (Sun et al., 2018)

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2018 , Cd010975 (2018)