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15 Phase II trials targeting MASH have shown that treatment with SEMA 0.4 mg daily for 72 weeks resulted in more patients with liver fibrosis stage F2/F3 achieving improvement in MASH without progression of liver fibrosis (odds ratio = 6.87, 95% CI = 2.6017.63) compared to placebo

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These setbacks suggest that a more direct way of targeting the extracellular domain of TLR4, rather than its co-receptors or the intracellular TIR domain, may offer better efficacy and therapeutic potential