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Another limitation was that both studies had low numbers of participants, with the fewest in the groups with severe renal or hepatic impairment

Researchers should note that despite GHK-Cus favorable safety profile, the subcutaneous or intramuscular administration of peptides in general is associated with injection site pain, lightheadedness, nausea, and even flu-like symptoms in subjects

Shibata et al

Improper Mixing: Shaking the vial instead of gently swirling it can damage the peptide

Any bacterial load introduced (dirty finger on septum, reused needle, vial left open) will be held at a threshold of a few tens to hundreds of CFU/ml for 14 to 28 days depending on initial inoculum and strain

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