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This apparently opposite behaviour remains mechanistically unresolved and requires independent replication

The World Obesity Federation states that nearly 2.8 billion people worldwide are affected by obesity 1

In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

Andreasen CR, Andersen A, Knop FK, Vilsboll T

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