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Renal shutdown has also been reported but usually only occurs after large, frequent doses of harsh chelators (19)

Living in a state of prolonged stress increases oxidative stress in the body, which may also lead to a faster depletion of L-glutathione

doi: 10.1016/J.SCITOTENV.2023.162713 106

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The shRNAs with the best KD efficiency were used in subsequent experiments either by transfection or packaged into adenoviruses for in vivo delivery

demonstrated that murine renal tubular epithelial cells become susceptible to ferroptosis with aging, marked by increased expression of the proferroptotic lipoxygenase-5 (lox-5) and reduced expression of GPX4